Professor Kemp Malone 1890-1972

Evan Malone

We report on ongoing investigations of the potential for Solid Free-form Fabrication (SFF) processes to autonomously manufacture entire fully functional complex electromechanical systems, and of the application of such technology to a selfsustained robot ecology. Two complementary approaches are considered: (a) A universal fabrication system capable of autonomously manufacturing arbitrary machi...

1972 , Volume , Issue Nov-1972

It makes swept insertion and return loss measurements simultaneously, overa wide frequency range. TO THE MICROWAVE ENGINEER, an instru ment that measures insertion and return loss simultaneously, over a broad band, would be as useful as is the voltmeter to other electronic special ists, provided it is made practical in several im portant ways. • Its measurements must really refer to the micro...

A redox-mediated Kemp eliminase

The acid/base-catalysed Kemp elimination of 5-nitro-benzisoxazole forming 2-cyano-4-nitrophenol has long served as a design platform of enzymes with non-natural reactions, providing new mechanistic insights in protein science. Here we describe an alternative concept based on redox catalysis by P450-BM3, leading to the same Kemp product via a fundamentally different mechanism. QM/MM computations...

Dmd059121 1890..1905

Subcutaneous injection is an important route of administration for therapeutic proteins that provides several advantages over other modes of parenteral delivery. Despite extensive clinical use, the exact mechanism underlying subcutaneous absorption of proteins is not completely understood, and the accuracy of prediction of absorption of biotherapeutics in humans remains unsatisfactory. This rev...

Harold Raistrick, 1890-1971.